Presented by Shane Needham, PhD at the 2026 AAPS National Biotechnology Conference (NBC), this presentation explores practical strategies for applying high-resolution mass spectrometry (HRMS) to quantitative bioanalysis.
The session focuses on improving sensitivity, selectivity and quantitative confidence across peptide and small molecule workflows while maintaining alignment with current bioanalytical guidelines.
Using real-world case studies and analytical workflows, the presentation highlights how HRMS-Based quantitation and MRMHR approaches can minimize interference, reduce background and support robust quantitative performance in complex biological matrices.
The presentation also highlights how optimized HRMS workflows can significantly improve laboratory efficiency and bioanalytical turnaround times, including examples where quantitative workflows supported up to 5x faster turnaround in select applications.
Topics include:
• HRMS-Based quantitation strategies for peptides and small molecules
• Improving selectivity and reducing matrix interference
• MRMHR workflows for complex biological matrices
• Achieving reproducible, accurate and guideline-aligned quantitative performance
• Practical approaches to accelerating bioanalysis and improving turnaround times
This presentation also highlights how advanced HRMS workflows are helping support faster decision-making and more efficient bioanalytical operations across modern drug development programs.
Download the presentation to explore how HRMS is advancing quantitative bioanalysis workflows.
